- One of the earliest proposals for the design of a mask to protect an individual against toxic fumes came from the notes of Leonardo da Vinci.
- The use of animals to detect biological agents was used as an early field detector in Hawaii shortly after the attack on Pearl Harbor. Fear of a follow-up Japanese biological attack led the Chemical Warfare Service to put small fish in aquariums at key locations.
- Johann Baptista van Helmont (1577-1644), born in Brussels, began to identify various gases given off by different processes like combustion, fermentation, and the heating of organic matter. While studying the chemistry of air, he shattered so many containers while generating gases from various chemical reactions, that he coined the term “gas” from the Greek word for chaos.
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